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Cannabidiol (CBD), the non-intoxicating compound in marijuana, continues drawing attention as a potential treatment for disorders and illnesses ranging from epilepsy to cancer. Now a new brain imaging study suggests that a single dose of CBD can reduce symptoms of psychosis by “resetting” activity in three brain areas. If replicable, the study offers the first evidence-based explanation for how CBD works in the brain to counteract psychosis and could open the door to new treatments.

Psychosis is not a single condition or disorder, but is rather a symptom of other disorders characterized by detachment from reality. Seeing, hearing or believing things that aren’t real, including hallucinations, is typical of a psychotic episode. While the exact causes of psychosis aren’t known, it’s thought to be triggered by mental illness, trauma, substance abuse and extreme stress. Even lack of sleep can spark an episode.

While psychosis is most often associated with schizophrenia, it actually affects a much larger segment of the population. At least 100,000 people a year experience their first onset of psychosis in the U.S., according to the National Institute of Mental Health.

This was a small study of 33 participants who were experiencing psychotic symptoms. A smaller group of healthy participants served as a control group. Half the psychosis group was given one dose of CBD, the other half received a placebo. Then all of the participants completed a memory task (designed to engage three brain areas that have been linked to the onset of psychosis) while their brains were examined with an MRI scanner.

The scans showed abnormal activity in the brains of the participants experiencing symptoms, as compared to the healthy control group – that much was expected. But the brains of those who had taken a dose of CBD showed less severe abnormalities than the brains of those who had taken a placebo, suggesting that the compound was “resetting” abnormal activity in the key brain areas.

“The results have started unravelling the brain mechanisms of a new drug that works in a completely different way to traditional anti-psychotics,” said the study’s lead author Dr. Sagnik Bhattacharyya from the Institute of Psychiatry, Psychology & Neuroscience at King’s College, London.

The next step, already underway, is a large-scale human trial to replicate the results and determine if CBD is a viable treatment.  If successful, the drug would be immediately differentiated from other meds on the market—including some that have been around since the 1950s—that produce inconsistent results. Some of the most common meds also have notoriously severe side effects, including muscle tremors and overpowering sedation.

“There is an urgent need for a safe treatment for young people at risk of psychosis,” added Dr. Bhattacharyya. “One of the main advantages of cannabidiol is that it is safe and seems to be very well tolerated, making it in some ways an ideal treatment.”

The study represents another big step forward for CBD as a treatment for brain-based disorders. Earlier this year, the US FDA approved the first drug comprised of CBD to treat severe forms of epilepsy.

Members of this research team conducted an earlier study showing that CBD seems to counterbalance the effects of tetrahydrocannabinol (THC), the psychoactive compound in marijuana that gets users high. THC has been linked to the onset of psychosis in some users and appears to mimic aspects of psychosis in the brain. If CBD turns out to be an effective anti-psychotic, these findings will highlight yet another striking paradox of a plant that science is only now really beginning to understand.

The study was published in JAMA Psychiatry.

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Original Article at https://www.forbes.com/sites/daviddisalvo/2018/08/31/study-cbd-from-marijuana-may-reset-the-brain-to-counteract-symptoms-of-psychosis/